منابع مشابه
Delta-Notch signalling in segmentation
Modular body organization is found widely across multicellular organisms, and some of them form repetitive modular structures via the process of segmentation. It's vastly interesting to understand how these regularly repeated structures are robustly generated from the underlying noise in biomolecular interactions. Recent studies from arthropods reveal similarities in segmentation mechanisms wit...
متن کاملThe Notch signalling pathway in hair growth
The Notch signalling pathway is an important mediator of cell fate selection whose involvement in epidermal appendage formation is now becoming recognised. Hair follicle development and hair formation involve the co-ordinated differentiation of several different cell types in which Notch appears to have a role. We report intricate expression patterns for the Notch-1 receptor and three ligands, ...
متن کاملDevelopmental Signalling: Vertebrate ligands for Notch
Newly discovered potential ligands for the Notch family of cell-cell signaling receptors illuminate the importance of lateral signaling during development and promise to help unravel signal transduction by Notch. During embryonic development, a cell's fate is determined by an interplay of environmental signals and heredity. Studies of invertebrates have identified a type of environmental signal...
متن کاملNotch signalling in ischaemia-induced angiogenesis.
Notch signalling represents a key pathway essential for normal vascular development. Recently, great attention has been focused on the implication of Notch pathway components in postnatal angiogenesis and regenerative medicine. This paper critically reviews the most recent findings supporting the role of Notch in ischaemia-induced neovascularization. Notch signalling reportedly regulates severa...
متن کاملGeneration of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells
Notch signalling occurs via direct cell-cell interactions and plays an important role in linking the fates of neighbouring cells. There are four different mammalian Notch receptors that can be activated by five cell surface ligands. The ability to inhibit specific Notch receptors would help identify the roles of individual family members and potentially provide a means to study and control cell...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2019
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2019.08.320